2005年 論文発表

分子遺伝学的検査

Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000

◆Journal of Atherosclerosis and Thrombosis 12: 240-250 (2005)
Hidenori Arai1, Akira Yamamoto2, Yuji Matsuzawa3, Yasushi Saito4, Nobuhiro Yamada5, Shinichi Oikawa6, Hiroshi mabuchi7, Tamio Teramoto8, Jun Sasaki9, Noriaki Nakaya10, Hiroshige Itakura11, Yuichi Ishikawa12, Yasuyoshi Ouchi13, Hiroshi Horibe14, Tohru Egashira15, Hiroaki Hattori15, Nobuo Shirahashi16, Toru Kita17 on behalf of the Research group on Serum Lipid Level Survey 2000 in Japan 
  1. Department of Geriatric Medicine, Kyoto University School of Medicine, Kyoto, Japan.
  2. National Cardiovascular Center, Osaka, Japan.
  3. Department of Internal Medicine, Osaka University, Osaka, Japan.
  4. Department of Internal Medicine, Chiba University, Chiba, Japan.
  5. Department of Internal Medicine, Tsukuba University, Ibaraki, Japan.
  6. Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
  7. Department of Internal Medicine, Kanazawa University, Ishikawa, Japan.
  8. Department of Internal Medicine, Teikyo University, Tokyo, Japan.
  9. International University of Health and Welfare, Tochigi, Japan.
  10. Fussa Hospital, Tokyo, Japan.
  11. Ibaraki Christian University, Ibaraki, Japan.
  12. Faculty of Health Sciences, Kobe University, Hyogo, Japan.
  13. Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.
  14. Keisen Clinic, Tokyo, Japan.
  15. Department of Advanced Technology and Development, BML, Inc., Saitama, Japan.
  16. Osaka City University Medical School, Osaka, Japan.
  17. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

The important role for βVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor

◆Journal of Human Genetics 49: 622-628 (2005)
Tadao Iwasaki1, Sadao Takahashi2, Mitsuaki Ishihara1, Masafumi Takahashi3, Uichi Ikeda3, Kazuyuki Shimada4, Takahiro Fujino5, Tokuo T. Yamamoto5, Hiroaki Hattori1, Mitsuru Emi6
  1. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  2. The Third Department of Internal Medicine, School of Medicine, Fukui University, Fukui, Japan.
  3. Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
  4. Division of Cardiology, Department of Medicine, Jichi Medical School, Tochigi, Japan.
  5. Gene Research Center, Tohoku University, Sendai, Japan.
  6. Department of Molecular Biology, Institute of Gerontology, Nippon Medical University School, Kawasaki, Japan.

Deficiency of the very low-density lipoprotein (VLDL) receptors
In streptozotocin-induced diabetic rats: insulin dependency of the VLDL receptor

◆Endocrinology 146: 3286-3294 (2005)
Tadao Iwasaki1, Sadao Takahashi2, Masao Takahashi4, Yasuo Zenimaru2, Takeshi Kujiraoka1, Mitsuaki Ishihara1, Makoto Nagano1, Jinya Suzuki2, Isamu Miyamori2, Hironobu Nakai3, Juro Sasaki5, 6, Takahiro Fujino7, Norman E. Miller8, Tokuo T. Yamamoto9, and Hiroaki Hattori1
  1. Department of Advanced Medical Technology and Development, BML, Inc., Kawagoe, Japan.
  2. Third Department of Internal Medicine, School of Medicine, Fukui University, Fukui, Japan.
  3. Second Department of Pathology, Fukui University, Fukui, Japan.
  4. Department of Cardiovascular Surgery, Hiratsuka Kyosai Hospital, Hiratsuka, Japan.
  5. Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Komaba, Japan.
  6. Exploratory Research for Advanced Technology of Japan Science and Technology Corp., Aomi, Japan.
  7. Department of Bioscience, Integrated Center for Science, Ehime University, Shigenobu, Japan.
  8. Department of Cardiovascular Biochemistry, St. Barts and Royal London School of Medicine, London, United Kingdom.
  9. Center for Advanced Genome Research, Institute of Aging, Development, and Cancer, Tohoku University, Sendai, Japan.

Interleukin-1β attenuates β-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells

◆Journal of Molecular and Cellular Cardiology 38: 637-646 (2005)
Masafumi Takahashi1, 2, Sadao Takahashi3, Chihiro Suzuki1, Lijing Jia1, Hajime Morimoto1, Hirohiko Ise1, Tadao Iwasaki4, Hiroaki Hattori4, Jinya Suzuki3, Isamu Miyamori3, Eiji Kobayashi2, Uichi Ikeda1
  1. Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Nagano, Japan.
  2. Divisions of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan.
  3. Third Department of internal medicine, Fukui University School of Medicine, Fukui, Japan.
  4. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.

Indications that paraoxonase-1 Contributes to plasma high density lipoprotein levels in familial hypercholesterolemia

◆Journal of Lipid Research 46: 445-451 (2005)
Thomas M. van Himbergen1, Mark Roest1, Jacqueline de Graaf2, Eugene H. J. M. Jansen3, Hiroaki Hattori4, John J. P. Kastelein5, Hieronymus A. M. Voorbij1, Anton F. H. Stalenhoef2, Lambertus J. H. van Tits2
  1. Research Laboratory of the Department of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands.
  2. Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands.
  3. Laboratory for Toxicology, Pathology, and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  4. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  5. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

A novel common variant-181 G insertion in the promoter of the gene for phospholipid transfer protein

◆Atherosclerosis 180: 211-213 (2005)
J. Palmen1, S.E. Humphries1, A. van Tol2, H. Hattori3, H.M. Colhoun4
  1. Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK.
  2. Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
  3. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  4. Department of Epidemiology and Public Health, Royal Free and University College London Medical School, Torrington Place, UK.

An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease

◆Clinical Cardiology 27: 641-644 (2004)
Reiko Ohmori1, Yukihiko Momiyama1, Makoto Nagano2, Hiroaki Taniguchi1, Tohru Egashira2, Atsushi Yonemura1, Haruo Nakamura1, Kazuo Kondo3, Fumitaka Ohsuzu1
  1. First Department of Internal medicine, National Defense Medical College, Saitama, Japan.
  2. Department of Advanced Technology and Development, BML, Inc., Saitama, Japan.
  3. Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.

LDL受容体C25S変異の機能解析

◆The Lipid 16: 207-212 (2005)
服部浩明1, 岩崎忠雄1, 石原光昭1, 高橋将文2
  1. 株式会社ビー・エム・エル先端医療開発部
  2. 信州大学大学院医学研究科臓器移植細胞工学医科学系専攻臓器発生制御医学

Fluorescence in situ hybridization monitoring of BCR-ABL-positive neutrophils in chronic myeloid leukemia patients during the primary stage of imatinib mesylate therapy

◆International Journal of Hematology 81: 235-241 (2005)
Naoto Takahashi1, 2, Ikuo Miura2, Yoshimi Kobayashi2, Masaaki Kume2, Tomoko Yoshioka2, Wataru Otane3, Kaori Ohtsubo4, Kaoru Takahashi5, Atsushi Kobayashi6, Yoshinari Kawabata2, Makoto Hirokawa2, Hirokazu Nishijima4, Ryo Ichinohasama7, John DeCoteau1, Akira B. Miura8, Ken-ichi Sawada2
  1. University of Saskatchewan, College of Medicine, Pathology Department and Saskatchewan Cancer Center, Saskatoon, Saskatchewan, Canada.
  2. Akita University School of Medicine, Third Department of Internal Medicine, Akita, Japan.
  3. BML, Inc., Cell Biology Section, Saitama, Japan.
  4. SRL Inc., Center for Molecular Biology and Cytogenetics, Tokyo, Japan.
  5. Japanese Red Cross Junior College of Akita, Akita, Japan.
  6. Akita Kumiai General Hospital, Internal Medicine, Akita, Japan.
  7. Tohoku University Graduate School of Dentistry, Oral Pathology, Sendai, Japan.
  8. Akita University, Akita, Japan.

Polymorphism of the 3'-Untranslated Region of Interleukin-12 p40 gene is not associated with the presence or severity of coronary artery disease

◆Circulation Journal 69: 793-797 (2005)
Yukiko Moriyama1, Reiko Ohmori1, Makoto Nagano2, Ryuichi Kato1, Hiroaki Taniguchi1, Tohru Egashira2, Haruo Nakamura3, Fumitaka Ohsuzu1
  1. First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  2. Department of Advanced Technology and Development, BML, Inc., Saitama, Japan.
  3. Mitsukoshi Health and Welfare Foundation, Tokyo, Japan.

Granulysin induces cell death with nuclear accumulation

◆Journal of Medical and Dental Sciences 52: 1-7 (2005)
Yasushi Takamori1, 2, Kazuyuki Ogawa1, Kinya Nagata1, Shoichi Takano1, Masataka Nakamura2
  1. Research and Development Center, BML, Inc., Saitama, Japan.
  2. Human gene Sciences center, Tokyo Medical and Dental University.

Colonic Paneth cell metaplasia is pre-neoplastic condition of colonic cancer or not?

◆Journal of Carcinogenesis 4: 5 (2005)
Ryo Wada1, 2, Toshikazu Yamaguchi3, Kenichi Tadokoro3
  1. The Department of Pathology, Juntendo Izunagaoka Hospital of Juntendo University School of Medicine, Shizuoka, Japan.
  2. The Department Pathology(Ⅰ), Juntendo University School of Medicine, Tokyo, Japan.
  3. R&D Center, BML, Inc., Saitama, Japan.

Pathological and molecular-biological studies on sequence from reflux esophagitis to development of Barrett's adenocarcinoma

◆Digestive Endoscopy 17: 64-68 (2005)
Ryo Wada1, 2, Toshikazu Yamaguchi3, Kenichi Tadokoro3
  1. Department of Pathology, Juntendo Izunagaoka Hospital of Juntendo University School of Medicine, Shizuoka, Japan.
  2. Department Pathology(Ⅰ), Juntendo University School of Medicine, Tokyo, Japan.
  3. R&D Center, BML, Inc., Saitama, Japan.

SNPs in the promoter region of osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C

◆Journal of Gastroenterology 40: 381-388 (2005)
Masashi Naito1, Atsushi Matsui1, Mie Inao1, Sumiko Nagoshi1, Makoto Nagano2, Nobuko Ito2, Tohru Egashira2, Michie Hashimoto3, Shunji Mishiro1, 3, Satoshi Mochida1, Kenji Fujiwara1
  1. Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical School, Saitama, Japan.
  2. Department of Gene Science, BML, Inc., Saitama, Japan.
  3. Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan.

Influence of CYP2C19 polymorphism and Helicobacter pylori genotype determined from gastric tissue samples on response to triple therapy for H. pylori Infection

◆Clinical Gastroenterology and Hepatology 3: 564-573 (2005)
Takahisa Furuta1, Yukiko Sagehashi2, Naohito Shirai3, Mitsushige Sugimoto1, Akiko Nakamura1, Makoto Kodaira4, Kazumi Kenmotsu2, Makoto Nagano2, Tohru Egashira2, Koji Ueda5, Masao Yoneyama5, Kyoichi Ohashi6, Takashi Ishizaki7, Akira Hishida1
  1. First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
  2. Department of Clinical Genomics, BML, Inc., Saitama, Japan.
  3. Department of Clinical Laboratories, Hamamatsu University School of Medicine, Shizuoka, Japan.
  4. Department of Gastroenterology, Yaizu City Hospital, Shizuoka, Japan.
  5. Daiichi Pure Chemicals Co, Ltd., Tokyo, Japan.
  6. Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Shizuoka, Japan.
  7. Department of Clinical Pharmacology and Pharmacy, School of Pharmaceutical Sciences, Teikyo-Heisei University, Tokyo, Japan.

ナノインベーダー法の開発と応用

◆臨床検査 49: 551-556 (2005)
野村幸男, 江頭徹
株式会社ビー・エム・エル先端技術開発本部臨床ゲノム開発部

Isolation of genes showing increased expression during bovine adipocyte differentiation

◆Animal Science Journal 76 : 479-489 (2005)
Tadashi Yamasaki1, 2, Miho Inoue-Murayama3, Koji Tahara2, Shoichi Takano2, Akinori Sugiyama3, Tomohito Itoh4, 5, Akiko Takasuga4, Yoshikazu Sugimoto4, Michael T. Rose6, Hisashi Aso7, Shinichi Ito3
  1. The United Graduate School of Agricultural Science, Gifu University, Gifu-shi.
  2. Research and Development Center, BML, Kawagoe-shi.
  3. Faculty of Applied Biological Sciences, Gifu University, Gifu-shi.
  4. Shirakawa Institute of Animal Genetics, Japan Livestock Technology Association, Nishigo-mura, Fukushima-ken.
  5. Livestock Improvement Association of Japan, Maebashi-shi.
  6. Institute of Rural Sciences, University of Wales, Aberystwyth, UK.
  7. Graduate School of Agricultural Sciences, Tohoku University, Aoba-ku, Sendai-shi, Japan

生化学的検査

Elective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase

◆Biochemical and Biophysical Research Communications 336: 1-8 (2005)
Yoshitaka Takahashi1, Hong Zhu2, Wanpeng Xu2, Takashi Murakami3, Tadao Iwasaki4, Hiroaki Hattori4, Tanihiro Yoshimoto2
  1. Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan.
  2. Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.
  3. Department of Molecular Function Analysis, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.
  4. Research Department, R&D Center, BML, Inc., Saitama, Japan.

A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration

◆Journal of Lipid Research 46: 2015-2022 (2005)
Mitsuaki Ishihara1, Takeshi Kujiraoka1, Tadao Iwasaki1, Makoto Nagano1, Mayumi Takano1, Jun Ishii2, Masahiro Tsuji3, Hajime Ide3, Irana P. Miller4, Norman E. Miller4, Hiroaki Hattori1
  1. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  2. Division of Internal medicine, Hokkaido Hospital for Social Health Insurance, Hokkaido, Japan.
  3. Institute of Medical Science, Health Science University of Hokkaido, Hokkaido, Japan.
  4. Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT. USA.

Human plasma phospholipids transfer protein activity is decreased by acute hyperglycaemia: studies without and with hyperinsulinaemia in Type 1 diabetes mellitus

◆Diabetic Medicine 22: 768-774 (2005)
P. H. N. Oomen1, A. van Tol1, 2, H. Hattori3, A. J. Smit4, L. M. Scheek1, R. P. F. Dullaart1
  1. Department of Endocrinology, University Hospital Groningen, Groningen, the Netherlands.
  2. Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
  3. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  4. Department of Internal medicine, University Hospital Groningen, Groningen, the Netherlands.

アポリポ蛋白J (apo J)

◆日本臨床 62(増刊12:広範囲血液・尿化学検査 免疫学的検査-2): 117-120 (2005)
鯨岡健, 高野真由美, 服部浩明
株式会社ビー・エム・エル先端医療開発部

シスタチンC測定用ラテックス凝集比濁法試薬「オート シスタチンC・BML」の性能評価

◆医学と薬学 54: 877-881 (2005)
八塚信明1, 石川美明2, 工藤康之2, 坪井五三美1
  1. 株式会社ビー・エム・エル試薬部
  2. 株式会社ビー・エム・エル免疫化学部

免疫学的検査

Non-IgE, -IgG4 antibody to Japanese cedar pollen allergens: comparison of its prevalence and titers between pollinosis patients and non-patients

◆Allergology International 54: 159-166 (2005)
Hiroshi Miyakawa1, Masahiro Sakaguchi2, Hiroshi Yasueda3, Saburo Saito4, Kazuya Tanaka5, Kinya Nagata5, Sakae Inouye6
  1. Department of Medical Technology, Kyorin University, Tokyo, Japan.
  2. Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  3. National Sagamihara Hospital, Kanagawa, Japan.
  4. Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan.
  5. Department of Clinical Genomics, BML, Inc., Saitama, Japan.
  6. Public Health Research Unit, Otsuma Women's University, Tokyo, Japan.

Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis

◆Cornea 24: Suppl.1: S66-S70 (2005)
Hiroshi Fujishima1, 2, Kazumi Fukagawa1, Naoko Okada1, 2, Yoji Takano1, Kazuo Tsubota1, Hiroyuki Hirai3, Kinya Nagata3, Kenji matsumoto4, and Hirohisa Saito4
  1. Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
  2. Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
  3. R&D Center, BML, Inc., Saitama, Japan.
  4. Genox Research Inc., Kanagawa, Japan, National Children's Medical Research Center, Tokyo, Japan, and Department of Allergy and Immunology, National Research Institute for Child Health and Development Laboratory Tokyo, Japan.

IL- 31 , IL- 32の発現と機能

◆臨床免疫 44: 345-348 (2005)
鈴木久皇1, 永田欽也1, 秋山暢丈2, 斎藤三郎2
  1. 株式会社ビー・エム・エル先端医療開発部
  2. 東京慈恵会医科大学DNA医学研究所分子免疫部

Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation

◆Transplantation 79: 821-827 (2005)
Yoshinobu Kanda1, Yutaka Komatsu2, Masaaki Akahane3, Shigeyuki Kojima4, Yuki Asano-Mori1, Minoru Tada2, Kumi Oshima1, Hiroyuki Isayama2, Seishi Ogawa1, Toru Motokura1, Shigeru Chiba1, Kuni Ohtomo3, Masao Omata2, Hisamaru Hirai1
  1. Department of Cell Therapy & Transplantation Medicine, University of Tokyo, Tokyo, Japan.
  2. Department of Gastroenterology, University of Tokyo, Tokyo, Japan.
  3. Department of Radiology, University of Tokyo, Tokyo, Japan.
  4. R&D Center, BML, Inc., Saitama, Japan.

Increase in killer-specific secretory protein of 37kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma

◆Clinical and Experimental Allergy 35: 643-649 (2005)
M. Kuepper1, 2, K. Bratke1, 2, P. Julius1, K. Ogawa3, 4, K. Nagata4, W. Luttmann1, J. C. Virchow Jr1
  1. Department of pneumology, Medical University Clinic, Rostock, Germany.
  2. Department of Zoophysiology, University Oldenburg, Oldenburg, Germany.
  3. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan.
  4. R&D Center, BML, Inc., Saitama, Japan.

20~39歳日本人女性の風疹免疫状況-臨床検査会社のデータから

◆感染症学雑誌 79: 375-380 (2005)
板橋愛宜1, 山本晋一1, 増井幸雄1, 井上栄2
  1. 株式会社ビー・エム・エル免疫化学部
  2. 大妻女子大学家政学部

慢性呼吸器疾患患者における23価肺炎球菌ワクチン接種前後の血清型特異抗体濃度の検討

◆日本呼吸器学会雑誌 43: 277-282 (2005)
斉藤若菜1, 永井英明1, 鈴木純子1, 益田公彦1, 田村厚久1, 長山直弘1, 赤川志のぶ1, 川辺芳子1, 町田和子1, 倉島篤行1, 四元秀毅1, 斉藤剛2, 新井智3, 岡部伸彦3
  1. 独立行政法人国立病院機構東京病院呼吸器内科
  2. 株式会社ビー・エム・エル
  3. 国立感染症研究所

神経生理学的検査

N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide

◆European Journal of Neuroscience 21: 733-740 (2005)
Ryutaro Oba1, Akira Igarashi1, Makiko Kamata1, Kinya Nagata1, Syoichi Takano1, Hachiro Nakagawa2
  1. R&D Center, BML, Inc., Saitama, Japan.
  2. Cooperative Research Center, Akita University, Akita, Japan.

微生物学的検査

各都道府県から分離された新鮮臨床分離株76万株の各種抗菌薬に対する感受性検査成績

◆診療と新薬 42: 980-1035 (2005)
霜島正浩
株式会社ビー・エム・エル安全性試験部

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