2006年 論文発表

分子遺伝学的検査

The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study Ⅱ

◆Diabetologia 49 : 2337-2340 (2006)
PJ Talmud1, JA Cooper1, H Hattori2, IP Miller3, GJ Miller4, SE Humphries1
  1. Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School.
  2. Department of Advanced Medical Technology and Development, Biomedical Laboratories Inc.
  3. Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine.
  4. Medical Research Council Cardiovascular Group, Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine.

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

◆Journal of Lipid Research 47 : 2064-2070 (2006)
Stefan F. C. Vaessen1, Frank G. Schaap2, Jan-Albert Kuivenhoven1, Albert K. Groen2, Barbara A. Hutten3, S. Matthijs Boekholdt4, Hiroaki Hattori5, Manjinder S. Sandhu6, Sheila A. Bingham7, Robert Luben6, Jutta A.Palmen8, Nicholas J. Waewham9, Steve E. Humphries8, John J. P. Kastelein1, Philippa J. Talmud8, Kay-Tee Khaw6
  1. Departments of Vascular Medicine.
  2. The Liver Center.
  3. Clinical Epidemiology and Biostatistics.
  4. Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
  5. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan.
  6. Institute of Public Health and Primary Care, Institute of Public Health, University of Cambridge, UK.
  7. Medical Research Council Dunn Nutrition Unit, Cambridge, UK.
  8. Department of Medicine, Rayne Institute, University College Medical School, London, UK.
  9. Medical Research Council Epidemiology Unit, Cambridge, UK.

Changes in cardiac lipid metabolism during sepsis: The essential role of very low-density lipoprotein receptors

◆Cardiovascular Research 69 : 545-555 (2006)
Lijing Jia1, Masafumi Takahashi1, Hajime Morimoto1, Sadao Takahashi2, Atsushi Izawa1, Hirohiko Ise1, Tadao Iwasaki3, Hiroaki Hattori3, Kou-Juey Wu4, Uichi Ikeda1
  1. Department of Organ Regeneration,Shinsyu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
  2. Third Department of Internal Medicine,Faculty of Medical Science, University of Fukui, Japan.
  3. Department of Advanced Medical Technology and Development, BML Inc., Saitama, Japan.
  4. Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.

Thr-encoding Allele Homozygosity at Codon 54 of FABP 2 Gene May be Associated with Impaired Delta 6 Desatruase Activity and Reduced Plasma Arachidonic Acid in Obese Children

◆Journal of Atherosclerosis and Thrombosis 13 : 192-196 (2006)
Tomoo Okada1, Noriko Sato1, Yuki Kuromori1, Michio Miyashita1, Fujihiko Iwata1, Mitsuhiko Hara1, Kensuke Harada1, Hiroaki Hattori2
  1. Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
  2. Research Department, R&D Center, BML, Inc., Kawagoe, Saitama, Japan.

Association between osteoprotegerin gene polymorphism and coronary artery disease in Japanese men

◆Atherosclerosis 187 : 215-217 (2006)
Ohmori R1, Momiyama Y1, Taniguchi H1, Tanaka N1, Kato R1, Nakamura H1, Ohsuzu F1, Nagano M2, Egashira T2
  1. National Defence Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
  2. BML, Saitama, Japan.

An atypical case of abetalipoproteinaemia with severe fatty liver in the absence of steatorrhoea or acanthocytosis

◆European Journal of Pediatrics 165 : 68-70 (2006)
Osamu Sakamoto1, Daiki Abukawa2, Junji Takeyama3, Nobuhiro Arai4, Makoto Nagano5, Hiroaki Hattori5, Tohru Egashira5, Naohiko Sakai6, Shizuya Yamashita6, Kazuie Iinuma1, Toshihiro Ohura1
  1. Department of Paediatrics, Tohoku University School of Medicine, Sendai, Japan.
  2. Department of General Paediatrics, Miyagi Childrens Hospital, Sendai, Japan.
  3. Department of Pathology, Miyagi Childrens Hospital, Sendai, Japan.
  4. Shiogama City Hospital, Shiogama, Japan.
  5. Department of Advanced Technologies and Development, BML Inc., Saitama, Japan. 6 Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Osaka, Japan.

Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor

◆Journal of Immunology 177 : 2621-2629 (2006)
Takahiro Satoh1, Rie Moroi1, Kosuke Aritake2, Yoshihiro Urabe2, Yasumasa Kanai1, Koji Sumi1, Hiroo Yokozeki1, Hiroyuki Hirai3, Kinya Nagata3, Toshifumi Hara4, Masanori Utsuyama5, Katsuiku Hirokawa5, Kazuo Sugamura6, Kiyoshi Nishioka1, Masataka Nakamura4
  1. Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  2. Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan.
  3. Department of Advanced Medicine and Development, Bio Medical Laboratories, Inc., Saitama, Japan.
  4. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan.
  5. Department of Comprehensive Pathology and Immunology, Tokyo Medical and Dental University, Tokyo, Japan. Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Significance of liver negative-strand HCV RNA quantitation in chronic hepatitis C

◆Journal of Hepatology 44 : 302-309 (2006)  
Nobukazu Yuki1, Shinji Matsumoto2, Kenichi Tadokoro2, Kiyoshi Mochizuki3, Michio Kato1, Toshikazu Yamaguchi2
  1. Department of Gastroentrology, Osaka national Hospital, Osaka, Japan.
  2. BML, Inc., Kawagoe, Japan. 3 Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.

Classification of hepatitis B virus genotypes by the PCR-Invader method with genotype-specific probes

◆Journal of Virological Methods 138 : 30-39 (2006)
Kenichi Tadokoro1, Mariko Kobayashi2, Toshikazu Yamaguchi1, Fumitaka Suzuki2, Saeko Miyauchi1, Toru Egashira1, Hiromitsu Kumada2
  1. Division of Advanced Technology and Development, BML, Inc., Kawagoe-shi, Saitama 350-1101, Japan.
  2. Research Institute for Hepatology, Toranomon Hospital, Kanagawa 213-8587, Japan.

Invader法による臨床検査項目の開発と応用-Helicobacter pyloriのクラリスロマイシン耐性遺伝子変異の検出系の開発を中心に-

◆臨床病理 54 : 176-183 (2006)
江頭徹
株式会社ビー・エム・エル臨床ゲノム開発部

Mechanism of plasma glutathione peroxidase production in bovine adipocytes

◆Cell and tissue research 326 : 139-147 (2006)   
Tadashi Yamasaki1, 5, Koji Tahara1, Shoichi Takano1, Miho Inoue-Murayama2, Michael T. Rose3, Takeshi Minashima4, Hisashi Aso4, Shin'ichi Ito2
  1. R&D Center, BML, 1361-1 Matoba, Kawagoe, 350-1101, Japan.
  2. Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
  3. Institute of Rural Sciences, University of Wales, Aberystwyth, SY23 3AL, UK.
  4. Cellular Biology Laboratory, Graduate School of Agricultural Sciences, Tohoku University, 1-1 Tsutsumi-dori Amamiyamachi, Aoba-ku, Sendai, 981-8555, Japan.
  5. The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

一塩基多型(SNP)を用いた牛の個体識別

◆月刊フードケミカル 1 : 84-87 (2006)
田中和也1, 野村幸男1, 江頭 徹1, 日佐和夫2
  1. 株式会社ビー・エム・エル
  2. 株式会社ビー・エム・エルフード・サイエンス

生化学的検査

Plasma apolipoprotein A5 and triglycerides in type 2 diabetes

◆Diabetologia 49 : 1505-1511 (2006)
GM Dallinga-Thie1, A van Tol2, H Hattori3, LC van Vark-van der ZeeH1, H Jansen4, EJG Sijbrands1, the DALI study group
  1. Department of Vascular Medicine and Metabolism, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
  2. Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
  3. Department of Endocrinology, University Medical Center Groningen,Groningen, The Netherlands.
  4. Department of Advanced Medical Technology and Development, BML, Saitama, Japan.
  5. Department of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Evidence for a complex relationship between apoA-V and apoC-Ⅲ in patients with severe hypertriglyceridemia

◆Journal of Lipid Research 47 : 2333-2339 (2006)
Frank G. Schaap1, Melchior C. Nierman2, Jimmy F. P. Berbee3, Hiroaki Hattori4, Philippa J. Talmud5, Stefan F. C. Vaessen2, Patrick C. N. Rensen3, Robert A. F. M. Chamuleau1, Jan Albert Kuivenhoven2, Albert K. Groen1, 6
  1. Academic Medical Center Liver Center, 1105 BK Amsterdam, The Netherlands.
  2. Departments of Vascular Medicine.
  3. Department of General Internal Medicine, Endocrinology, and Metabolism, Leiden University Medical center, 2300 RC Leiden, The Netherlands.
  4. Department of Advanced Medical Technology and Development, BML, Inc., Kawagoe, Saitama 350-1101, Japan.
  5. Department of Medicine, Royal Free and University College Medical School, Royne Institute, London WC1E 6JF, UK.
  6. Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.

Serum Apolipoprotein J in Health, Coronary Heart Disease and Type 2 Diabetes Mellitus

◆Journal of Atherosclerosis and Thrombosis 13 : 314-322 (2006)
Takeshi Kujiraoka1, Hiroaki Hattori1, Yoshikazu Miwa2, Mitsuaki Ishihara1, Takahiro Ueno3, Jun Ishii4, Masahiro Tsuji5, Tadao Iwasaki1, Yoshiyuki Sasaguchi2, Takayuki Fujioka3, Satoshi Saito3, Motoo Tsushima6, Taro Maruyama6, Irina P. Miller7, Norman E. Miller7, Tohru Egashira1
  1. Department of Advanced Medical Technology and Development, BML Inc., Kawagoe, Japan.
  2. Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
  3. The second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
  4. Hokkaido Hospital for Social Insurance, Sapporo, Japan.
  5. Hokkaido Health Science University, Sapporo, Japan.
  6. Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
  7. Cardiovascular Genetics Division, University School of Utah School of Medicine, Salt Lake City, USA, and Oxford Lipid Group, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

Plasma phospholipid transfer protein activity is decreased in type 2 diabetes during treatment with atorvastatin : a role for apolipoprotein E?

◆Diabetes 55:1491-1496 (2006)
Geesje M.Dallinga-Thie1, Arie van Tol2, 3, Hiroaki Hattori4, Patrick C. N. Rensen5, Eric J. G. Sijbrands1, for the Diabetes Atorvastatin Lipid Intervention (DALI) Study Group
  1. Department of Internal Medicine, Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam, the Netherlands.
  2. Department of Cell Biology and Genetics, Erasmus Medical Center, Rotterdam, the Netherlands.
  3. Department of Endocrinology and Metaboliosm, University Medical Center Groningen, Groningen, the Netherlands.
  4. Advanced Medical Technology and Development, BML, Saitama, Japan.
  5. Departments of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, the Netherlands.

Platelet-activating factor acetylhydrolase concentration in children with abdominal obesity

◆Arterioscler Thromb Vasc Biol. May; 26 (5) e-40-1 (2006)
Okada T1, Miyashita M1, Kuromori Y1, Iwata F1, Harada K1, Hattori H2
  1. Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
  2. Research Department, R&D Center, BML, Inc., Kawagoe, Saitama, Japan.

免疫学的検査

Analysis of Serum Granulysin in Patients With Hematopoietic Stem-Cell Transplantation: Its Usefulness as a Marker of Graft-Versus-Host Reaction

◆American Journal of Hematology 81: 340-348 (2006)
Masayuki Nagasawa1, Takeshi Isoda1, Sukeyuki Itoh1, Michiko Kajiwara1, Tomohiro Morio1, Norio Shimizu2, Kazuyuki Ogawa3, Kinya Nagata3, Masataka Nakamura4, Shuki Mizutani1
  1. Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  2. Department of Virology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  3. B.M.L. R&D Center, Saitama, Japan. 4 Human Gene Sciences Center, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Plasma granulysin concentrations and preeclampsia risk

◆Clinical Biochemistry 39 : 1016-1021 (2006)
Chunfang Qiu1, Shigeru Saito2, Masatoshi Sakai2, Kazuyuki Ogawa3, Kinya Nagata3, Michelle A. Williams1
  1. Center for Perinatal Studies, Swedish Medical Center, Seattle, WA98104, USA.
  2. Department of Obstetrics and Gynaecology, University of Toyama, Toyama, Japan.
  3. R&D Center, BML, Saitama, Japan.

Expression of granulysin in polymyositis and inclusion-body myositis

◆J Neurol Neurosurg Psychiatry 77: 1187-1190 (2006)
K Ikezoe1, S Ohshima1, M Osoegawa1, M Tanaka1, K Ogawa2, K Nagata2, J-i Kira1
  1. Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
  2. Research and Development Center, BML, Saitama, Japan.

Exhaustive Exercise Induces Differential Changes in Serum Granulysin Circulating Number of Natural Killer Cells

◆The Tohoku journal of experimental medicine 210: 117-124 (2006)
Xiumin Zhang1, Kaori Matsuo1, Arta Farmawati1, Yohei Higashi1, Kazuyuki Ogawa2, Kinya Nagata2, Ryoichi Nagatomi1
  1. Department of Medicine and Science in Sports and Exercise, Tohoku University School of Medicine, Sendai, Japan.
  2. R&D Center, BML, Saitama, Japan.

新しいサイトカインIL-31

◆リウマチ科 35 : 282-289 (2006)
永田欽也1, 鈴木久皇1, 秋山暢丈2, 斎藤三郎2, 山本三毅夫3
  1. 株式会社ビー・エム・エル先端医療開発部
  2. 東京慈恵会医科大学DNA医学研究所分子免疫部
  3. 防衛医科大学校生化学第二

プロスタグランジンD2

◆アレルギーの臨床 26 : 522-527 (2006)
平井博之  株式会社ビー・エム・エル

Apoptotic process of porcine intestinal M cells

◆Cell and tissue research 323 : 425-432 (2006)
Kotaro Miyazawa1, Hisashi Aso1, Takashi Kanaya1, Takemoto Kido1, Takeshi Minashima1, Kouichi Watanabe1, Shyuichi Ohwada1, Haruki Kitazawa2, Michael T. Rose3, Koji Tahara4, Tadashi Yamasaki4, Takahiro Yamaguchi1
  1. Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, 981-8555 Sendai, Japan.
  2. Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, 981-8555 Sendai, Japan.
  3. Institute of Rural Sciences, University of Wales, Aberystwyth, SY23 3AL, UK.
  4. R&D Center, BML, 350-1101 Saitama, Japan.

微生物学的検査

各都道府県から分離された新鮮臨床分離株80万株の各種抗菌薬に対する感受性検査成績 (第4報:2005年4月~2006年3月)

◆診療と新薬 43: 697-753 (2006)
霜島正浩
株式会社ビー・エム・エル細胞形態学部細菌学課

2004年臨床分離株の各種経口抗菌薬に対する感受性

◆Pharma Medica 24: 109-119 (2006)
小川美保, 市村禎宏, 平野英二, 霜島正浩, 瀬戸勇
株式会社ビー・エム・エル細胞形態学部細菌学課

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