2008年 論文発表

分子遺伝学的検査

インベーダー法によるミトコンドリア遺伝子点変異スクリーニング検査

◆Medical Science Digest 34:366-369 (2008)
長野誠1, 伊藤伸子1, 加藤万由子2, 田所健一1, 江頭徹1, 後藤雄一2
  1. 株式会社ビー・エム・エル臨床ゲノム部
  2. 国立精神・神経センター神経研究所疾病研究第二部

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients

◆Journal of Lipid Research 49:1846-1854 (2008)
Clive R. Pullinger1, 2, Bradley E. ASouizerat2, 3, Irina Movseyan1, Vincent Durlach6, Eric J. Sijbrands7, Katsuyuki Nakajima8, Annie Poon1, Geesje M. Dallinga-Thie9, Hiroaki Hattori10, Lauri L. Green2, Pui-Yan Kwok1, Richard J. Havel1, Philip H. Frost1, 4, Mary J. Malloy1, 4, John P. Kane1, 4, 5
  1. Cardiovascular Research Institute
  2. Department of Physiological Nursing
  3. Institute for Human Genetics
  4. Department of Medicine
  5. Department of Biochemistry and Biophysics, University of Caslifornia, San Francisco, CA
  6. Servise d' Endcrinologie, Maladies Metabolique, et Medicine Interne, Hopital Robert Debre, Reims Cedex, France
  7. Department of Cardiovascular Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
  8. Japan Immunoresearch Laboratories Co., Takasaki Gunma, Japan
  9. Laboratory of Experimental Vascular Medicine, Academisch Medisch Centrum, Amsterdam, The Netherlands
  10. Department of Advanced Medical Technology and Development, BML, Inc., Kawagoe, Saitama, Japan

CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice

◆Journal of Immunology 180:5680-5688 (2008)
Rie Nomiya1, Mitsuhiro Okano1, Tazuko Fujiwara1, Megumi Maeda2, Yoshinobu Kimura2, Kosuke Kino3, Minehiko Yokoyama3, Hiroyuki Hirai4, Kinya Nagata4, Toshifumi Hara5, Kazunori Nishizaki1, Masataka Nakamura5
  1. Department of Otalaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  2. Division of Biomolecular Science, The Graduate School of Natural Science and Technology, Okayama University, Okayama,Japan
  3. Meiji Company, Odawara, Japan
  4. Department of Advanced Medicine and Development, BioMedical Laboratories, Saitama, Japan
  5. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan

Lipopolysaccharide Induces Macrophage Migration via Prostaglandin D2 and Prostaglandin E2

◆Journal of Phamacology and Experimental Therapeutics 326:493-501 (2008)
Tsuyoshi Tajima1, Takahisa Murata1, Kosuke Aritake2, Yoshihiro Urade2, Hiroyuki Hirai3, Masataka Nakamura4, Hiroshi Ozaki1, Masatoshi Hori2
  1. Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences
  2. Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
  3. Department of Advanced Medicine and Development, Bio Medical Laboratories, Inc., Saitama, Japan
  4. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan

16rRNA遺伝子およびITS-1領域をターゲットとしたInvader法による23菌種の抗酸菌の同定 -臨床分離株を用いたDDH法との比較検討-

◆結核 83:487-486 (2008)
長野誠1, 市村禎宏2, 伊藤伸子1, 富井貴之2, 鹿住祐子3, 武井勝明2, 阿部千代治4, 5, 菅原勇3
  1. 株式会社ビー・エム・エル臨床ゲノム部
  2. 株式会社ビー・エム・エル安全性試験部
  3. 結核予防会結核研究所抗酸菌レファレンスセンター
  4. 株式会社ビー・エム・エル
  5. 日本ベクトン・ディッキンソン株式会社

生化学的検査

Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus

◆Metabolism Clinical and Experimental 57:453-457(2008)
Yoshiharu Tokuyama1, Toshiharu Ishizuka1, Kana Matsui2, Toru Egashira2, Azuma Kanatsuka1, Sachio Nomura1, Masatoshi Kondo2, Makoto Nagano1, Kana Matsui1, Toru Egashira1
  1. Diabetes Center, Chiba Central Medical Center, Chiba 246-0017, Japan
  2. Division of Clinical Development, R&D Center, BML Inc., Kawagoe 350-1101, Japan

Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells

◆Biomedical and Biophysical Research Communications 368:716-722 (2008)
Yasuo Zenimaru1, Sadao Takahashi1, Masafumi Takahashi2, Kazuya Yamada3, Tadao Iwasaki4, Hiroaki Hattori4, Michiko Imagawa1, Masami Ueno1, Jinya Suzuki1, Isamu Miyamori1
  1. Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui 910-1193, Japan
  2. Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, Matsumoto 390-1101, Japan
  3. Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, Matsumoto 390-1295, Japan
  4. Department of Advanced Medical Technology and Development, BML, Inc., Kawagoe 350-1101, Japan

Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment

◆Athrosclerosis 196 (2008) 931-936
Masanori Iwase1, Kazuo Sonoki1, Nobuhiro Sasaki1, Shigehiro Ohdo2, Shun Higuchi2, Hiroaki Hattori3, Mitsuo Iida1
  1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan
  2. Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyusyu University, Fukuoka, Japan
  3. Department of Advanced Medical Technology and Development, BML, Inc., Saitama, Japan

S-1長期投与後の尿中ウラシル値の変動と再発との関係の検討

◆癌と化学療法 35:947-950 (2008)
森本茂文1, 辻毅2, 庄野嘉治3, 秋山功4, 藤田芳一5, 長谷川健次1, 田伏克惇3
  1. 独立行政法人国立病院機構大阪南医療センター薬剤科
  2. 独立行政法人労働者健康福祉機構和歌山労災病院外科
  3. 独立行政法人国立病院機構大阪南医療センター外科
  4. 株式会社ビー・エム・エル環境検査科
  5. 大阪薬科大学臨床化学教室

免疫学的検査

フローサイトメーターを用いたトール様受容体2の定量的解析

◆Cytometry Research 18 (1) : 25-29, 2008
大葉龍太郎1, 平井博之1, 永田欽也1, 野間芳弘2, 坂本淳2, 折原弘治3, 浜崎秀一3, 鄭忠和3
  1. 株式会社ビー・エム・エル先端医療開発部
  2. 株式会社ビー・エム・エル特殊分析部
  3. 鹿児島大学大学院循環器・呼吸器・代謝内科学

Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion

◆American Journal of Pathology 173:653-664 (2008)
Akitoshi Nakashima1, Arihiro Shiozaki1, Subaru Myojo1, Mika Ito1, Mikiko Tatematsu1, Masatoshi Sakai1, Yasushi Takamori2, Kazuyuki Ogawa3, Kinya Nagata3, Shigeru Saito1, 4
  1. The Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama
  2. The Stem Cell Institute Inc., Tokyo
  3. The R&D Center, BML, Saitama
  4. The 21st Century COE Program, University of Toyama, Toyama

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis

◆American International Journal of Hematology 83:222-225 (2008)
Masayuki Nagasawa1, Zhu Yi1, Shinsaku Imasyuku2, Shigeaki Nonoyama3, Kazuyuki Ogawa4, Ko Okumura5, Shuki Mizutani1
  1. Department of Pediatrics and Development Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  2. Department of Pediatrics, Kyoto Prefectural University, Tokyo, Japan
  3. Department of Pediatrics, National Defense Medical School, Saitama, Japan
  4. B.M.L. R&D Center and Laboratory Headquarters, Saitama, Japan
  5. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

Toll-like receptor 2 expression level on monocytes in patients with viral infections: Monitoring infection severity

◆Journal of infection 57:249-259 (2008)
Takashi Kajiya1, Koji Orihara1, Shuichi Hamasaki1, Ryutaro Oba2, Hiroyuki Hirai2, Kinya Nagata2, Tomoaki Kumagai2, Sanemasa Ishiba1, Naoya Oketani1, Hitoshi Ichiki1, So Kuwahata1, Shoji Fujita1, Nobuhiro Uemura3, Chuwa Tei1
  1. Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Mediine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan
  2. Department of Advanced Medicine and Development, BML, INC. Saitama, Japan
  3. Kouseikai Uemura Hospital, Kagoshima, Japan

Time-course of Toll-like receptor 2 expression, as a predictor of recurrence in patients with bacterial infectious diseases

◆Clinical and Experimental Immunology 148:260-270 (2008)
K. Orihara1, K.Nagata2, S.Hamasaki1, R.Oba2, H.Hirai2, S.Ishida1, T.Kataoka1, N.Oketani1, M.Ogawa1, E.Mizoguchi1, H.Ichiki1, C.Tei1
  1. Department of Cardiovascular, Respiratory and Metabolic, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
  2. Department of Advanced Medicine and Development, BML, Inc., Saitama, Japan

CRTH2-dependent, STAT6-independent induction of cedar pollen dermatitis

◆Clinical and Experimental Allergy 38:1357-1366 (2008)
M.Oiwa1, T.Satoh1, M.Watanabe1, H.Niwa1, H.Hirai2, M.Nakamura3, H.Yokozeki1
  1. Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  2. Department of Advanced Medicine and Development, BML Inc., Saitama, Japan
  3. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan

Cyclooxygenase-2/Prostaglandin D2/CRTH2 Pathway Mediates Double-Stranded RNA-Induced Enhancement of Allergic Airway Inflammation

◆Journal of Immunology 180:541-549 (2008)
Yoshiki Shiraishi1, 3, Koichiro Asano1, 3, Kyoko Niimi1, 3, Koichi Fukunaga1, 3, Misa Wakaki1, 3, Junko Kagyo1, 3, Takahisa Takihara1, 3, Soichiro Ueda1, 3, Takeshi Nakajima1, 3, Tsuyoshi Oguma1, 3, Yusuke Suzuki1, Tetsuya Shiomi1, Koichi Sayama1, Shizuko Kagawa1, 3, Eiji Ikeda2, Hiroyuki Hirai4, Kinya Nagata4, Masataka Nakamura5, Taku Miyasho6, Akitoshi Ishizaka1, 3
  1. Division of Pulmonary Medicine, Department of Medicine
  2. Department of Pathology
  3. Shinanomachi Research Park, Keio University School of Medicine, Tokyo, Japan
  4. Department of Advanced Medicine and Development, BML, Inc., Saitama, Japan
  5. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan
  6. Laboratory of Veterinary Biochemistry, Rakuno Gakuen University, Ebetsu, Japan

微生物学的検査

2007年東京圏青年層での麻疹流行 臨床検査会社のIgM抗体検査データの解析

◆感染症学雑誌 82:198-204 (2008)
伴文彦1, 増井幸雄1, 井上栄2
  1. 株式会社ビー・エム・エル
  2. 大妻女子大学家政学部

各都道府県から分離された新鮮臨床分離株79万株の各種抗菌薬に対する感受性検査成績(第6報:2007年4月~2008年3月)

◆診療と新薬 45:697-753 (2008)
霜島正浩(株式会社ビー・エム・エル細胞形態学部細菌学課)

Analysis of herpes simplex virus type 1 restriction fragment length polymorphism variants associated with herpes gladiatorum and Kaposi's varicelliform eruption in sumo wrestlers

◆Journal of General Virology 89: 2410-2415 (2008)
Ban F1, 2, Asano S3, Ozawa S4, Eda H1, Norman J5, Stroop WG5, Yanagi K1
  1. Herpesvirus Laboratory ,Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
  2. BML General Institute, Saitama, Japan
  3. Department of Dermatology, Doai Kinen Hospital, Tokyo, Japan
  4. Yamanashi Institute of Health Yamanashi, Japan, 5 Department of Ophthalmology, Baylor College of Medicine, TX, USA

Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections

◆Antimicrobial agents and chemotherapy 52: 2061-2068 (2008)
Higashide M1, 2, Kuroda M1, 3, Omura CT1, Kumano M1, Ohkawa S4, Ichimura S5, Ohta T1
  1. Department of Microbiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
  2. Kotobiken Medical Laboratories Inc., Ibaraki, Japan
  3. Laboratory of Bacterial Genomics, Center for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan
  4. Department of Microbiology, Kohjin Bio Co., Ltd., Saitama, Japan
  5. Department of Bacteriology, BML, Inc., Saitama, Japan

その他

エアーシューターによる検体搬送

◆Medical Technology 36:1098-1099 (2008)
木村ひろみ1, 2, 鷹取明美1, 2, 中義久1,2, 木村聡3
  1. 昭和大学横浜市北部病院臨床検査部
  2. 株式会社ビー・エム・エル
  3. 昭和大学横浜市北部病院臨床検査科

単行著書(分担執筆)

アレイCGHの検査レベルの取り組み(1)~いかに染色体検査を補完していくか~

◆アレイCGH診断活用ガイドブック 知っておきたい染色体微細構造異常症(稲沢譲治他 編) p.40-42, 医薬ジャーナル社, 2008
山口敏和1, 会津善紀2
  1. 株式会社ビー・エム・エル臨床ゲノム部
  2. 同先端医療開発部

アレイCGHの検査レベルの取り組み(2)~いかに解析精度を保証するか~

◆アレイCGH診断活用ガイドブック 知っておきたい染色体微細構造異常症(稲沢譲治他 編) p.43-46, p.50, 医薬ジャーナル社, 2008
山口敏和1, 会津善紀2
  1. 株式会社ビー・エム・エル臨床ゲノム部
  2. 同先端医療開発部

種々の染色体・ゲノム検査法

◆アレイCGH診断活用ガイドブック 知っておきたい染色体微細構造異常症(稲沢譲治他 編) p.66-71, 医薬ジャーナル社, 2008
山口敏和1, 会津善紀2, 稲澤譲治3
  1. 株式会社ビー・エム・エル臨床ゲノム部
  2. 同先端医療開発部
  3. 東京医科歯科大学難治疾患研究所ゲノム応用医学研究部門分子細胞遺伝分野

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