2011年 論文発表

分子遺伝学的検査

Long-term Follow-up of Chronic Pancreatitis Patients with K-ras Mutation in the Pancreatic Juice

◆Hepato-Gastroenterology 2011;58(105):174-176
Terumi Kamisawa1, Kensuke Takuma1, Taku Tabata1, Naoto Egawa1, Toshikazu Yamaguchi2
  1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
  2. Division of Clinical Development of Biomedical Laboratories, Saitama, Japan

Comparative quantitative analysis of BCR-ABL transcripts with the T315I mutant clone by polymerase chain reaction (PCR)-Invader method

◆Translational Research 2011;158(3):169-179
Kenichi Tadokoro1, Maho Ishikawa2, Makoto Suzuki1, Tomoyoshi Saito1, Yoshie Suzuki1, Toshikazu Yamaguchi1, Fumiharu Yagasaki2
  1. Development of Clinical Genomics, BML, Inc., Saitama, Japan
  2. Department of Hematology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan

Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies

◆Journal of Human Genetics 2011;56(2):110-124
Shin Hayashi1, 2, Issei Imoto1, 3, Yoshinori Aizu4, Nobuhiko Okamoto5, Seiji Mizuno6, Kenji Kurosawa7, Nana Okamoto1, 8, Shozo Honda1, Satoshi Araki9, Shuki Mizutani9, Hironao Numabe10, Shinji Saitoh11, Tomoki Kosho12, Yoshimitsu Fukushima12, Hiroshi Mitsubuchi13, Fumio Endo13, Yasutsugu Chinen14, Rika Kosaki15, Torayuki Okuyama15, Hirotaka Ohki16, Hiroshi Yoshihashi17, Masae Ono18, Fumio Takada19, Hiroaki Ono20, Mariko Yagi21, Hiroshi Matsumoto22, Yoshio Makita23, Akira Hata24, Johji Inazawa1, 25
  1. Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo
  2. Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo
  3. Department of Human Genetics and Public Health Graduate School of Medical Science, The University of Tokushima, Tokushima
  4. Division of Advanced Technology and Development, BML, Saitama
  5. Department of Medical Genetics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka
  6. Department of Pediatrics, Central Hospital Aichi Human Service Center, Kasugai
  7. Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama
  8. Department of Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  9. Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Graduate School, Tokyo
  10. Department of Medical Genetics, Kyoto University Hospital, Kyoto
  11. Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo
  12. Department of Medical Genetics, Shinsyu University School of Medicine, Matsumoto
  13. Department of Pediatrics, Kumamoto University Graduate School of Medical Science, Kumamoto
  14. Department of Pediatrics, University of the Ryukyu School of Medicine, Okinawa
  15. Department of Clinical Genetics and Molecular Medicine, National Center for Child Health and Development, Tokyo
  16. The Division of Cardiology, Tokyo Metropolitan Children's Medical Center, Tokyo
  17. The Division of Medical Genetics, Tokyo Metropolitan Children's Medical Center, Tokyo
  18. Department of Pediatrics, Tokyo Teishin Hospital, Tokyo
  19. Department of Medical Genetics, Kitasato University Graduate School of Medical Sciences, Sagamihara
  20. Department of Pediatrics, Hiroshima Prefectural Hospital, Hiroshima
  21. Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe
  22. Department of Pediatrics, National Defense Medical College, Saitama
  23. Education Center, Asahikawa Medical College, Asahikawa
  24. Department of Public Health, Chiba University Graduate School of Medicine, Chiba
  25. Global Center of Excellence (GCOE) Program for ‘International Research Center for Molecular Science in Tooth and Bone Diseases,’ Tokyo Medical and Dental University, Tokyo, Japan

生化学的検査

Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression

◆Biochemical and Biophysical Research Communications 2011;407(4):656-662
Sadao Takahashi1, 2, Takashi Ito3, Yasuo Zenimaru1, Jinya Suzuki1, Isamu Mimori1, Masao Takahashi4, Masafumi Takahashi5, Takafumi Ishida6, Tatsuro Ishida7, Ken-ichi Hirata7, Tokuo T. Yamamoto8, Tadao Iwasaki9, Hiroaki Hattori9, Masashi Shiomi3, 10
  1. Third Department of Internal Medicine, University of Fukui, Faculty of Medical Science, Japan
  2. Research and Education Program for Life Science, University of Fukui, Faculty of Medical Science, Japan
  3. Institute for Experimental Animals, Kobe University Graduate School of Medicine, Japan
  4. Department of Cardiovascular Surgery, Hiratsuka Kyosai Hospitgal, Japan
  5. Division of Bioimaging Sciences, Center for Molecular Medicine, Jichi Medical University, Japan
  6. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science, Japan
  7. Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan
  8. Center for Advanced Genome Research, Institute of Development, Aging, and Cancer, Tohoku University, Japan
  • Department of Advanced Medical Technology and Development, BML, Inc. , Japan
  1. Section of Animal Models for Cardiovascular Diseases, Kobe University Graduate School of Medicine, Japan

免疫学的検査

Dual Functions of Prostaglandin D2 in Murine Contact Hypersensitivity via DP and CRTH2

◆American Journal of Pathology 2011;179(1):420-430
Yoshihiro Yamamoto1, Shinobu Otani1, Hiroyuki Hirai2, Kinya Nagata2, Kosuke Aritake3, Yoshihiro Urade3, Shuh Narumiya4, Hiroo Yokozeki1, Masataka Nakamura5, Takahiro Satoh1
  1. The Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo
  2. The Department of Advanced Medicine and Development, Bio Medical Laboratories, Inc., Saitama
  3. The Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka
  4. The Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto
  5. The Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan

Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway

◆Clinical and Experimental Immunology 2011;163(2):260-269
M.Eguchi1, S.Kariya1, M.Okano1, T.Higaki1, S.Makihara1, T.Fujiwara1, K.Nagata2, H.Hirai2, S.Narumiya3, M.Nakamura4, K.Nishizaki1
  1. Department of Otolaryngology-Head and Neck Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
  2. Department of Advanced Medicine and Development, BML, Inc., Saitama
  3. Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto
  4. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan

Role of Prostaglandin D2 Receptor CRTH2 in Sustained Eosinophil Accumulation in the Airways of Mice with Chronic Asthma

◆International Archives of Allergy and Immunology 2011;155(suppl.1):6-11
Shizuko Kagawa1, Koichi Fukunaga1, Tsuyoshi Oguma1, Yusuke Suzuki1, Tetsuya Shiomi1, Koichi Sayama1, Tokuhiro Kimura2, Hiroyuki Hirai4, KinyaNagata4, Masataka Nakamura3, Koichiro Asano1
  1. Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  2. Department of Pathology, Keio University School of Medicine, Tokyo
  3. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo
  4. R&D Center, BML Laboratories, Saitama

Reevaluation of Quantitative Flow Cytometric Analysis for TLR2 on Monocytes Using F(ab')2 Fragments of Monoclonal Antibodies

◆Cytometry A 2011;79(4):247-255
Ryutaro Oba1, 2, Koji Orihara3, Tomoaki Kumagai1, Hiroyuki Hirai1, Kinya Nagata1, Shuichi Hamasaki3, Chuwa Tei3, Nakamura Masataka2
  1. Department of Advanced Medicine and Development, BML Inc., Saitama
  2. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo
  3. Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima

Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum

◆Clinical and Experimental Dermatology 2011;36(8):903-907
O. Yamasaki1, S. Morizane1, S. Aochi1, K. Ogawa2, T. Oono1, K. Iwatsuki1
  1. Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama
  2. R&D Center, BML, Saitama

First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin

◆American Journal of Reproductive Immunology 2011;66(5):363-372
Danijela Veljkovic Vujaklija1, Tamara Gulic1, Sonja Sucic1, Kinya Nagata2, Kazuyuki Ogawa2, Gordana Laskarin1, Shigeru Saito3, Herman Haller4, Daniel Rukavina1
  1. Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
  2. R&D Center BML, Saitama, Japan
  3. Department of Pbstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
  4. Department of Obstetrics and Gynecology, Clinical Hospital Center, Rijeka, Croatia

Autoantibodies against cardiac troponin I in patients presenting with myocarditis

◆CVD Prevention and Control 2011;6, 41-46
Akira Matsumori1, Toshio Shimada2, Hiroaki Hattori3, Miho Shimada1, Jay W. Mason4
  1. Department of Cardiology, Tokyo Medical University, Tokyo, Japan
  2. Shizuoka General Hospital, Shizuoka, Japan
  3. Department of Advanced Medical Technology and Development, BML Inc., Saitama, Japan
  4. University of Utah, Salt Lake City, USA

Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches.

◆Mol Cell Proteomics 2011;10(6):M110.005330
Yasuhiro Katsumata1, Yasushi Kawagochi1, Sayumi Bana1, Seisuke Hattori2, 3, Koji Tahara4, Kaori Ito4, Tadao Iwasaki4, Nozomi Yamaguchi4, Masaaki Oyama5, Hiroko Kozuka-Hata5, Hiroaki Hattori4, Kinya Nagata4, Hisashi Yamanaka1, Masako Hara1
  1. Institute of Rheumatology, Tokyo Women's Medical Science, University
  2. Division of Cellular Proteomics (BML), Institute of Medical Science, University of Tokyo
  3. Division of Biochemistry, School of Pharmaceutical Science, Kitasato University
  4. Advanced Medical Technology and Development, BML
  5. Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

乳児早期消化管型牛乳アレルギー患児における牛乳特異抗原によるリンパ球刺激試験について

◆アレルギーの臨床2011; 31:255-260
橋口明彦, 松尾久美子, 木村光明
株式会社ビー・エム・エル

微生物学的検査

各都道府県から分離された新鮮臨床分離株105 万株の各種抗菌薬に対する感受性検査成績(第9 報:2010年4月~2011年3月)

◆診療と新薬2011; 48:905-965
霜島正浩
株式会社ビー・エム・エル

日本全国から分離された淋菌の抗菌薬感受性に関する調査

◆感染症学雑誌2011; 85:360-365
田中正利, 霜島正浩, 雑賀威, 伊与田貴子, 池田文昭, 金山明子, 小林寅哲
株式会社ビー・エム・エル

新規アレルギー検査法の生物製剤および抗ウイルス薬への応用

◆医薬品の品質管理とウイルス安全性 2011:279-365
平井博之
BML総合研究所先端医療開発部

Copyright© BML,INC All Rights Reserved.

page top